Studies on Antimalarial Sulfanilamides

N4Methyl and N4Dimethyl Substituted Sulfanilamides

The purpose of this study was to determine whether acetylation of the sulfonamide drugs in the human body could be prevented by substituting a simple alkyl radicle on the amino group of the drug without otherwise impairing the efficiency of its therapeutic action. Methyl and dimethyl substituted sulfanilamides were made and investigated from a pharmacological and therapeutic viewpoint. Because ...

Studies on the Action of Antimalarial Remedies on Monkey Malaria

Studies on the Action of Synthetic Antimalarial Drugs on Indian Strains of Malaria

Cilional was introduced by Schulemann of Messrs. Bayer-Meister-Lucius, Germany, a few years ago. It belongs to the plasmochin series of preparations and has the composition di-alkylamino-alkyl-amino-oxy-quinoline. Its action on the gametocyte of Plasmodium falciparum was claimed to be as potent as that of plasmochin, in doses far less than, any that produced toxic symptoms. A total dose of 0.18...

Activating interactions of sulfanilamides with T cell receptors

Activation and expansion of drug reactive T cells are key features in drug hypersensitivity reactions. Drugs may interact directly with immune receptors such as the human leukocyte antigens (HLA) or the T-cell receptors (TCR) itself, the pharmacological interaction [p-i] concept. To analyze whether the drug sulfamethoxazole (SMX) interacts directly with the TCR and thereby contributing to signa...

Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies

In this study, the antimalarial and toxicity potentials of husk fibre extracts of five Nigerian varieties of Cocos nucifera were evaluated in vitro. The only active extract fraction, West African Tall (WAT) ethyl acetate extract fraction, was then evaluated for its phytochemical constituents, antimalarial and toxicity potentials at varying doses (31.25-500 mg/kg body weight) using various organ...